Full list of Publications: Robert Roach, PhD

Acute hypoxia impairs dynamic cerebral autoregulation: Results from two independent techniques. Subudhi AW, Panerai RB, Roach RC., J Appl Physiol. 2009 Aug 6. [Epub ahead of print]

Effect of ventilation on cerebral oxygenation during exercise: insights from canonical correlation., Heine M, Subudhi AW, Roach RC., Respir Physiol Neurobiol. 2009 Apr 30;166(2):125-8. Epub 2009 Mar 5.

Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m., Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Christians U, Henthorn TK, Honigman B., Free Radic Biol Med. 2009 Jun 1;46(11):1551-7. Epub 2009 Mar 19.

Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia., Subudhi AW, Miramon BR, Granger ME, Roach RC., J Appl Physiol. 2009 Apr;106(4):1153-8. Epub 2009 Jan 15.

Inferring cerebrovascular changes from latencies of systemic and intracranial pulses: a model-based latency subtraction algorithm., Hu X, Subudhi AW, Xu P, Asgari S, Roach RC, Bergsneider M., J Cereb Blood Flow Metab. 2009 Apr;29(4):688-97. Epub 2009 Jan 14.

Hypoxemia and acute mountain sickness: which comes first?, Loeppky JA, Icenogle MV, Charlton GA, Conn CA, Maes D, Riboni K, Gates L, Melo MF, Roach RC., High Alt Med Biol. 2008 Winter;9(4):271-9.

Mortality on Mount Everest, 1921-2006: descriptive study. Firth PG, Zheng H, Windsor JS, Sutherland AI, Imray CH, Moore GW, Semple JL, Roach RC, Salisbury RA., BMJ. 2008 Dec 11;337:a2654. doi: 10.1136/bmj.a2654.

Endurance performance at altitude., Subudhi AW, Roach RC., Curr Sports Med Rep. 2008 Feb;7(1):6-7. No abstract available.

Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: a longitudinal cohort study., Sutherland AI, Morris DS, Owen CG, Bron AJ, Roach RC.

Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance., Subudhi AW, Lorenz MC, Fulco CS, Roach RC., Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H164-71. Epub 2007 Nov 21.

Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise., Subudhi AW, Dimmen AC, Roach RC., J Appl Physiol. 2007 Jul;103(1):177-83. Epub 2007 Apr 12.

Doppler ultrasound determination of the distribution of human cardiac output: effects of age and physical stresses., Greene ER, Roach RC., Conf Proc IEEE Eng Med Biol Soc. 2004;5:3704-7.

Role of hypobaria in fluid balance response to hypoxia., Loeppky JA, Roach RC, Maes D, Hinghofer-Szalkay H, Roessler A, Gates L, Fletcher ER, Icenogle MV., High Alt Med Biol. 2005 Spring;6(1):60-71.

Early fluid retention and severe acute mountain sickness., Loeppky JA, Icenogle MV, Maes D, Riboni K, Hinghofer-Szalkay H, Roach RC., J Appl Physiol. 2005 Feb;98(2):591-7. Epub 2004 Oct 22.

High altitude cerebral edema., Hackett PH, Roach RC., High Alt Med Biol. 2004 Summer;5(2):136-46. Review.

Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives., Bernardi L, Roach RC, Keyl C, Spicuzza L, Passino C, Bonfichi M, Gamboa A, Gamboa J, Malcovati L, Schneider A, Casiraghi N, Mori A, Leon-Velarde F., Adv Exp Med Biol. 2003;543:161-75. Review.

Body temperature, autonomic responses, and acute mountain sickness., Loeppky JA, Icenogle MV, Maes D, Riboni K, Scotto P, Roach RC., High Alt Med Biol. 2003 Fall;4(3):367-73.

Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude., Møller K, Paulson OB, Hornbein TF, Colier WN, Paulson AS, Roach RC, Holm S, Knudsen GM., J Cereb Blood Flow Metab. 2002 Jan;22(1):118-26.

Frontiers of hypoxia research: acute mountain sickness., Roach RC, Hackett PH., J Exp Biol. 2001 Sep;204(Pt 18):3161-70. Review.

Oral contraceptives, exercise, and acute mountain sickness in women., Sandoval DA, Maes DP, D'Acquisto L, Icenogle M, Roach RC., Aviat Space Environ Med. 2001 Aug;72(8):733-8.

High-altitude illness., Hackett PH, Roach RC., N Engl J Med. 2001 Jul 12;345(2):107-14. Review. No abstract available.

Ventilation is greater in women than men, but the increase during acute altitude hypoxia is the same., Loeppky JA, Scotto P, Charlton GC, Gates L, Icenogle M, Roach RC., Respir Physiol. 2001 Apr;125(3):225-37.

Exercise exacerbates acute mountain sickness at simulated high altitude., Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, Hinghofer-Szalkay H, Lium D, Loeppky JA., J Appl Physiol. 2000 Feb;88(2):581-5.

Dynamic cerebral autoregulation at high altitude., Levine BD, Zhang R, Roach RC., Adv Exp Med Biol. 1999;474:319-22. No abstract available.

Arterial O2 content and tension in regulation of cardiac output and leg blood flow during exercise in humans., Roach RC, Koskolou MD, Calbet JA, Saltin B., Am J Physiol. 1999 Feb;276(2 Pt 2):H438-45.

Arterial oxygen saturation for prediction of acute mountain sickness., Roach RC, Greene ER, Schoene RB, Hackett PH., Aviat Space Environ Med. 1998 Dec;69(12):1182-5.

The influence of PaO2, pH and SaO2 on maximal oxygen uptake., Nielsen HB, Madsen P, Svendsen LB, Roach RC, Secher NH., Acta Physiol Scand. 1998 Sep;164(1):89-7.

Skeletal muscle blood flow in humans and its regulation during exercise., Saltin B, Rådegran G, Koskolou MD, Roach RC., Acta Physiol Scand. 1998 Mar;162(3):421-36. Review.

Cardiovascular responses to dynamic exercise with acute anemia in humans., Koskolou MD, Roach RC, Calbet JA, Rådegran G, Saltin B., Am J Physiol. 1997 Oct;273(4 Pt 2):H1787-93.

Hypoxia and the cardiovascular response to dynamic knee-extensor exercise., Koskolou MD, Calbet JA, Rådegran G, Roach RC., Am J Physiol. 1997 Jun;272(6 Pt 2):H2655-63.

Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria., Loeppky JA, Icenogle M, Scotto P, Robergs R, Hinghofer-Szalkay H, Roach RC., Respir Physiol. 1997 Mar;107(3):231-9.

Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia., Roach RC, Loeppky JA, Icenogle MV., J Appl Physiol. 1996 Nov;81(5):1908-10.

Acute ventilatory response to simulated altitude, normobaric hypoxia, and hypobaria., Loeppky JA, Scotto P, Roach RC., Aviat Space Environ Med. 1996 Nov;67(11):1019-22.

Sea-level physical activity and acute mountain sickness at moderate altitude., Honigman B, Read M, Lezotte D, Roach RC., West J Med. 1995 Aug;163(2):117-21.

How well do older persons tolerate moderate altitude?, Roach RC, Houston CS, Honigman B, Nicholas RA, Yaron M, Grissom CK, Alexander JK, Hultgren HN., West J Med. 1995 Jan;162(1):32-6.

Relationship between whole blood base excess and CO2 content in vivo., Loeppky JA, Fletcher ER, Roach RC, Luft UC., Respir Physiol. 1993 Oct;94(1):109-20.

Effects of prolonged head-down bed rest on physiological responses to moderate hypoxia., Loeppky JA, Roach RC, Selland MA, Scotto P, Greene ER, Luft UC., Aviat Space Environ Med. 1993 Apr;64(4):275-86.

Body fluid alterations during head-down bed rest in men at moderate altitude., Loeppky JA, Roach RC, Selland MA, Scotto P, Luft FC, Luft UC., Aviat Space Environ Med. 1993 Apr;64(4):265-74.

The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison., Hackett PH, Roach RC, Hartig GS, Greene ER, Levine BD., Int J Sports Med. 1992 Oct;13 Suppl 1:S68-71.

Effects of acid-base status on acute hypoxic pulmonary vasoconstriction and gas exchange., Loeppky JA, Scotto P, Riedel CE, Roach RC, Chick TW., J Appl Physiol. 1992 May;72(5):1787-97.

Acetazolamide in the treatment of acute mountain sickness: clinical efficacy and effect on gas exchange., Grissom CK, Roach RC, Sarnquist FH, Hackett PH., Ann Intern Med. 1992 Mar 15;116(6):461-5.

Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing., Swenson ER, Leatham KL, Roach RC, Schoene RB, Mills WJ Jr, Hackett PH., Respir Physiol. 1991 Dec;86(3):333-43.

Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema., Levine BD, Grayburn PA, Voyles WF, Greene ER, Roach RC, Hackett PH., Ann Intern Med. 1991 Apr 1;114(7):569-70. No abstract available.

Operation Everest II: ventilatory adaptation during gradual decompression to extreme altitude., Schoene RB, Roach RC, Hackett PH, Sutton JR, Cymerman A, Houston CS., Med Sci Sports Exerc. 1990 Dec;22(6):804-10.

Accuracy of heart-rate monitoring and activity diaries for estimating energy expenditure., Kalkwarf HJ, Haas JD, Belko AZ, Roach RC, Roe DA., Am J Clin Nutr. 1989 Jan;49(1):37-43.

Dexamethasone for prevention and treatment of acute mountain sickness., Hackett PH, Roach RC, Wood RA, Foutch RG, Meehan RT, Rennie D, Mills WJ Jr., Aviat Space Environ Med. 1988 Oct;59(10):950-4.

The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema., Schoene RB, Swenson ER, Pizzo CJ, Hackett PH, Roach RC, Mills WJ Jr, Henderson WR Jr, Martin TR., J Appl Physiol. 1988 Jun;64(6):2605-13.

Abnormal control of ventilation in high-altitude pulmonary edema., Hackett PH, Roach RC, Schoene RB, Harrison GL, Mills WJ Jr., J Appl Physiol. 1988 Mar;64(3):1268-72.

Medical therapy of altitude illness., Hackett PH, Roach RC., Ann Emerg Med. 1987 Sep;16(9):980-6. Review.

Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide., Hackett PH, Roach RC, Harrison GL, Schoene RB, Mills WJ Jr., Am Rev Respir Dis. 1987 Apr;135(4):896-8.

High-altitude pulmonary edema. Characteristics of lung lavage fluid., Schoene RB, Hackett PH, Henderson WR, Sage EH, Chow M, Roach RC, Mills WJ Jr, Martin TR., JAMA. 1986 Jul 4;256(1):63-9.

Clove cigarettes and high-altitude pulmonary edema., Hackett PH, Rodriguez G, Roach RC., JAMA. 1985 Jun 28;253(24):3551-2. No abstract available.

High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure., Schoene RB, Roach RC, Hackett PH, Harrison G, Mills WJ Jr., Chest. 1985 Mar;87(3):330-3.

Acute mountain sickness, antacids, and ventilation during rapid, active ascent of Mount Rainier., Roach RC, Larson EB, Hornbein TF, Houston CS, Bartlett S, Hardesty J, Johnson D, Perkins M., Aviat Space Environ Med. 1983 May;54(5):397-401.

Acute mountain sickness and acetazolamide. Clinical efficacy and effect on ventilation., Larson EB, Roach RC, Schoene RB, Hornbein TF., JAMA. 1982 Jul 16;248(3):328-32.